InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prpf4

Summary

InnateDB Protein

IDBP-153134.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prpf4

Protein Name

PRP4 pre-mRNA processing factor 4 homolog (yeast)

Synonyms

1600015H11Rik; AI874830; AW047464; bN189G18.1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000081572

InnateDB Gene

IDBG-153132 (Prpf4)

Protein Structure

UniProt Annotation

Function

Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus speckle {ECO:0000250}. Note=Colocalizes with spliceosomal snRNPs. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	62 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0006397	mRNA processing
GO:0008380	RNA splicing

Cellular Component

GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0015030	Cajal body
GO:0016607	nuclear speck
GO:0071001	U4/U6 snRNP

Protein Structure and Domains

PDB ID

MGI:1917302

InterPro

IPR001680 WD40 repeat
IPR003648 Splicing factor motif
IPR014906 Pre-mRNA processing factor 4 (PRP4)-like
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat

PFAM

PF00400
PF08799

PRINTS

PR00320

PIRSF

SMART

SM00320
SM00500

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt