InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stat1

Summary

InnateDB Protein

IDBP-153164.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stat1

Protein Name

signal transducer and activator of transcription 1

Synonyms

2010005J02Rik; AA408197;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000066743

InnateDB Gene

IDBG-153162 (Stat1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 174 interaction(s) predicted by orthology.

Experimentally validated
Total	78 [view]
Protein-Protein	29 [view]
Protein-DNA	49 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	174 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000983	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0031730	CCR5 chemokine receptor binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001937	negative regulation of endothelial cell proliferation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0007259	JAK-STAT cascade
GO:0007584	response to nutrient
GO:0008015	blood circulation
GO:0008284	positive regulation of cell proliferation
GO:0009612	response to mechanical stimulus
GO:0009617	response to bacterium
GO:0014070	response to organic cyclic compound
GO:0016525	negative regulation of angiogenesis
GO:0019221	cytokine-mediated signaling pathway
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032496	response to lipopolysaccharide
GO:0032869	cellular response to insulin stimulus
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0034097	response to cytokine
GO:0034240	negative regulation of macrophage fusion
GO:0035458	cellular response to interferon-beta
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330	response to exogenous dsRNA
GO:0043434	response to peptide hormone
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0051591	response to cAMP
GO:0061326	renal tubule development

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0030424	axon
GO:0030425	dendrite

Protein Structure and Domains

PDB ID

MGI:103063

InterPro

IPR000980 SH2 domain
IPR008967 p53-like transcription factor, DNA-binding
IPR013799 STAT transcription factor, protein interaction
IPR013800 STAT transcription factor, all-alpha
IPR013801 STAT transcription factor, DNA-binding
IPR015988 STAT transcription factor, coiled coil
IPR022752 Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal

PFAM

PF00017
PF14633
PF02865
PF01017
PF02864
PF12162

PRINTS

PR00401

PIRSF

SMART

SM00252
SM00964

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt