InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ttf1

Summary

InnateDB Protein

IDBP-153192.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ttf1

Protein Name

transcription termination factor, RNA polymerase I

Synonyms

AV245725; TTF-1; TTF-I;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000097809

InnateDB Gene

IDBG-153217 (Ttf1)

Protein Structure

UniProt Annotation

Function

Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. {ECO:0000269PubMed:15292447, ECO:0000269PubMed:7720715, ECO:0000269PubMed:9049305, ECO:0000269PubMed:9267035}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:7720715}. Nucleus, nucleolus {ECO:0000269PubMed:7720715}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding

Biological Process

GO:0006338	chromatin remodeling
GO:0006355	regulation of transcription, DNA-templated
GO:0006361	transcription initiation from RNA polymerase I promoter
GO:0006363	termination of RNA polymerase I transcription
GO:0008156	negative regulation of DNA replication