Version 5.4
Mus musculus Protein: Metrn
Summary
InnateDB Protein IDBP-153195.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Metrn
Protein Name meteorin, glial cell differentiation regulator
Synonyms 1810034B16Rik; Hyrac;
Species Mus musculus
Ensembl Protein ENSMUSP00000002344
InnateDB Gene IDBG-153193 (Metrn)
Protein Structure
UniProt Annotation
Function Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia. {ECO:0000269PubMed:15085178}.
Subcellular Localization Secreted {ECO:0000269PubMed:15085178}.
Disease Associations
Tissue Specificity Highly expressed in brain. Expressed in undifferentiated neural progenitors and in astrocyte lineage, particulary in Bergmann glia, a subtype of radial glia, and a few discrete neuronal populations residing in the superior colliculus, the ocular motor nucleus, the raphe and pontine nuclei, and in various thalamic nuclei. Weakly expressed in heart, kidney, skeletal muscle, spleen, testis, gut and lung. {ECO:0000269PubMed:15085178, ECO:0000269PubMed:19259827}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0010001 glial cell differentiation
GO:0050772 positive regulation of axonogenesis
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:1917333
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8C1Q4
PhosphoSite PhosphoSite-
TrEMBL A2RSN4
UniProt Splice Variant
Entrez Gene 70083
UniGene
RefSeq
MGI ID
MGI Symbol Metrn
OMIM
CCDS CCDS28529
HPRD
IMGT
EMBL BC008695 BC037181 BC062118 BC132177 CH466606 DQ133462
GenPept AAH08695 AAH37181 AAH62118 AAI32178 AAZ41748 EDL22454

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca