InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Edar

Summary

InnateDB Protein

IDBP-153319.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Edar

Protein Name

ectodysplasin-A receptor

Synonyms

dl; ED1R; ED3; ED5; EDA-A1R; EDA3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003312

InnateDB Gene

IDBG-153317 (Edar)

Protein Structure

UniProt Annotation

Function

Receptor for EDA isoform TAA, but not for EDA isoform TA-2 (By similarity). May mediate the activation of NF-kappa-B and JNK. May promote caspase-independent cell death. {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Note=Defects in Edar are a cause of the downless phenotype in mice (the equivalent of anhidrotic ectodermal dysplasia in humans). The disease is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0001942	hair follicle development
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0030154	cell differentiation
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043473	pigmentation
GO:0060662	salivary gland cavitation