Version 5.4
Mus musculus Protein: Pole3
Summary
InnateDB Protein IDBP-153518.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pole3
Protein Name polymerase (DNA directed), epsilon 3 (p17 subunit)
Synonyms 1810034K18Rik; YBL1;
Species Mus musculus
Ensembl Protein ENSMUSP00000030091
InnateDB Gene IDBG-153516 (Pole3)
Protein Structure
UniProt Annotation
Function Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Ubiquitously expressed.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006261 DNA-dependent DNA replication
Cellular Component
GO:0005622 intracellular
GO:0008622 epsilon DNA polymerase complex
Protein Structure and Domains
PDB ID MGI:1933378
InterPro IPR003958 Transcription factor CBF/NF-Y/archaeal histone
IPR009072 Histone-fold
PFAM PF00808
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JKP7
PhosphoSite PhosphoSite-Q9JKP7
TrEMBL
UniProt Splice Variant
Entrez Gene 59001
UniGene Mm.400792
RefSeq NP_067473
MGI ID
MGI Symbol Pole3
OMIM
CCDS CCDS18244
HPRD
IMGT
EMBL AF230806 BC024996
GenPept AAF67146 AAH24996

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca