InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bsx

Summary

InnateDB Protein

IDBP-153728.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bsx

Protein Name

brain specific homeobox

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000068057

InnateDB Gene

IDBG-153726 (Bsx)

Protein Structure

UniProt Annotation

Function

DNA binding protein that function as transcriptional activator. Is essentiel for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti- related peptide function and locomotory behavior in the control of energy balance. {ECO:0000269PubMed:17353277, ECO:0000269PubMed:17485440, ECO:0000269PubMed:17550780}.

Subcellular Localization

Isoform 1: Nucleus.Isoform 2: Cytoplasm.

Disease Associations

Tissue Specificity

Expressed in brain. In brain, it is restricted to a few specific developing brain structures such as pineal gland, telencephalic septum, hypothalamic pre-mammillary body and arcuate nucleus. {ECO:0000269PubMed:14678827}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007420	brain development
GO:0007626	locomotory behavior
GO:0042755	eating behavior
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060056	mammary gland involution