InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Accn5

Summary

InnateDB Protein

IDBP-154096.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Accn5

Protein Name

amiloride-sensitive cation channel 5, intestinal

Synonyms

Accn5; Blinac; Inac;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029641

InnateDB Gene

IDBG-154094 (Accn5)

Protein Structure

UniProt Annotation

Function

Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium and lithium, and is inhibited by amiloride (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in cerebellum, brainstem, kidney, liver, hepatocytes, lung, intestine and embryo. {ECO:0000269PubMed:10457052}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005272	sodium channel activity
GO:0015252	hydrogen ion channel activity
GO:0015280	ligand-gated sodium channel activity

Biological Process

GO:0006814	sodium ion transport
GO:0015992	proton transport
GO:0035725	sodium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1929259

InterPro

IPR001873 Na+ channel, amiloride-sensitive

PFAM

PF00858

PRINTS

PR01078

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9R0Y1

PhosphoSite

PhosphoSite-

TrEMBL

D3Z0S5

UniProt Splice Variant

Entrez Gene

58170

UniGene

Mm.88839

RefSeq

NP_067345

MGI ID

MGI Symbol

Asic5

OMIM

CCDS

CCDS17428

HPRD

IMGT

EMBL

AC131757 AC159260 Y19035

GenPept

CAB54040