InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Casp3

Summary

InnateDB Protein

IDBP-154308.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Casp3

Protein Name

caspase 3

Synonyms

A830040C14Rik; AC-3; Apopain; CASP-3; Caspase-3; CC3; CPP-32; CPP32; Lice; mldy; SCA-1; Yama;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000091238

InnateDB Gene

IDBG-154306 (Casp3)

Protein Structure

UniProt Annotation

Function

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp--Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Highest expression in spleen, lung, liver, kidney and heart. Lower expression in brain, skeletal muscle and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 97 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	97 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004190	aspartic-type endopeptidase activity
GO:0004197	cysteine-type endopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process
GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis

Biological Process

GO:0001782	B cell homeostasis
GO:0001836	release of cytochrome c from mitochondria
GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0007507	heart development
GO:0007605	sensory perception of sound
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009411	response to UV
GO:0009611	response to wounding
GO:0016485	protein processing
GO:0030182	neuron differentiation
GO:0030216	keratinocyte differentiation
GO:0030218	erythrocyte differentiation
GO:0030889	negative regulation of B cell proliferation
GO:0034349	glial cell apoptotic process
GO:0043029	T cell homeostasis
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0045165	cell fate commitment
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045786	negative regulation of cell cycle
GO:0046007	negative regulation of activated T cell proliferation
GO:0051402	neuron apoptotic process
GO:0071310	cellular response to organic substance
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:0097194	execution phase of apoptosis
GO:1902510	regulation of apoptotic DNA fragmentation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:107739

InterPro

IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR002138 Peptidase C14, caspase non-catalytic subunit p10
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core

PFAM

PF00656

PRINTS

PR00376

PIRSF

SMART

SM00115

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt