InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chst3

Summary

InnateDB Protein

IDBP-154464.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chst3

Protein Name

carbohydrate (chondroitin 6/keratan) sulfotransferase 3

Synonyms

C6ST; C6ST-1; GST-0;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000065010

InnateDB Gene

IDBG-154462 (Chst3)

Protein Structure

UniProt Annotation

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N- acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen. {ECO:0000269PubMed:11696535, ECO:0000269PubMed:9597547}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Highly expressed in spleen, lung, eye and stomach. Constitutively expressed at low level during the mid- to late-gestation period. Expressed in the brain in a temporally controlled manner: peaks at 2 weeks after birth in the cerebellum, but at 3 weeks in the cerebrum. Localizes to stromal cells in the bone marrow, and stromal cells in the marginal zone and red pulp of the spleen, but the sense probe did not. {ECO:0000269PubMed:9597547}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008146	sulfotransferase activity
GO:0008459	chondroitin 6-sulfotransferase activity
GO:0050698	proteoglycan sulfotransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0043029	T cell homeostasis

Cellular Component

GO:0000139	Golgi membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1858224

InterPro

IPR000863 Sulfotransferase domain
IPR016469 Carbohydrate sulfotransferase
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00685

PRINTS

PIRSF

PIRSF005883

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O88199

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

53374

UniGene

Mm.12866

RefSeq

MGI ID

MGI Symbol

Chst3

OMIM

CCDS

HPRD

IMGT

EMBL

AB008937 AB008938 AB062109 BC055055

GenPept

AAH55055 BAA29054 BAA29055 BAB72166