InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYO1G

Summary

InnateDB Protein

IDBP-15451.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYO1G

Protein Name

myosin IG

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000258787

InnateDB Gene

IDBG-15449 (MYO1G)

Protein Structure

UniProt Annotation

Function

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). {ECO:0000250}.Precursor of the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:20071333}; Peripheral membrane protein {ECO:0000269PubMed:20071333}. Note=Localization at the membrane is not highly dependent on phosphatidylinositol 4,5-bisphosphate levels. Released from the membrane in the presence of ATP. May be enriched in peripheral processes, such as microvilli or ruffles.

Disease Associations

Tissue Specificity

Specifically expressed in hematopoietic cells. {ECO:0000269PubMed:11544309, ECO:0000269PubMed:20071333}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.