InnateDB Protein
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IDBP-154667.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Uimc1
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Protein Name
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ubiquitin interaction motif containing 1
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Synonyms
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9430016E08Rik; D330018D10Rik; D630032M02Rik; RIP110; Rxrip110;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000026997
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InnateDB Gene
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IDBG-154665 (Uimc1)
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Protein Structure
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Function |
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
64 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:103185
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InterPro |
IPR003903
Ubiquitin interacting motif
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PFAM |
PF02809
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PRINTS |
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PIRSF |
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SMART |
SM00726
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TIGRFAMs |
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Modification |
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SwissProt |
Q5U5Q9
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PhosphoSite |
PhosphoSite-Q5U5Q9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
20184
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UniGene |
Mm.399045
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RefSeq |
NP_035437
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MGI ID |
3A1Q
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MGI Symbol |
Uimc1
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OMIM |
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CCDS |
CCDS36671
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HPRD |
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IMGT |
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EMBL |
AK052704
AK083342
AK160926
BC037092
BC040808
U22015
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GenPept |
AAC52167
AAH37092
AAH40808
BAC35106
BAC38875
BAE36094
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