InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sfrp2

Summary

InnateDB Protein

IDBP-154793.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sfrp2

Protein Name

secreted frizzled-related protein 2

Synonyms

AI851596; Sdf5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029625

InnateDB Gene

IDBG-154791 (Sfrp2)

Protein Structure

UniProt Annotation

Function

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Highly expressed in the eye. Weaker expression in heart and lung. {ECO:0000269PubMed:9096311}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	6 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0010577	metalloenzyme activator activity
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042813	Wnt-activated receptor activity
GO:0048018	receptor agonist activity
GO:0061133	endopeptidase activator activity

Biological Process

GO:0001569	patterning of blood vessels
GO:0001756	somitogenesis
GO:0001843	neural tube closure
GO:0002063	chondrocyte development
GO:0003151	outflow tract morphogenesis
GO:0003214	cardiac left ventricle morphogenesis
GO:0006915	apoptotic process
GO:0007420	brain development
GO:0007584	response to nutrient
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008584	male gonad development
GO:0009952	anterior/posterior pattern specification
GO:0010629	negative regulation of gene expression
GO:0010667	negative regulation of cardiac muscle cell apoptotic process
GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0010950	positive regulation of endopeptidase activity
GO:0021915	neural tube development
GO:0030111	regulation of Wnt signaling pathway
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030199	collagen fibril organization
GO:0030307	positive regulation of cell growth
GO:0030308	negative regulation of cell growth
GO:0030336	negative regulation of cell migration
GO:0030514	negative regulation of BMP signaling pathway
GO:0031668	cellular response to extracellular stimulus
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0035413	positive regulation of catenin import into nucleus
GO:0036342	post-anal tail morphogenesis
GO:0042127	regulation of cell proliferation
GO:0042493	response to drug
GO:0042662	negative regulation of mesodermal cell fate specification
GO:0042733	embryonic digit morphogenesis
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043508	negative regulation of JUN kinase activity
GO:0045600	positive regulation of fat cell differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045766	positive regulation of angiogenesis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046546	development of primary male sexual characteristics
GO:0048546	digestive tract morphogenesis
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0051216	cartilage development
GO:0060028	convergent extension involved in axis elongation
GO:0060349	bone morphogenesis
GO:0061056	sclerotome development
GO:0061185	negative regulation of dermatome development
GO:0071425	hematopoietic stem cell proliferation
GO:0071481	cellular response to X-ray
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090175	regulation of establishment of planar polarity
GO:0090179	planar cell polarity pathway involved in neural tube closure
GO:0090244	Wnt signaling pathway involved in somitogenesis
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000035	regulation of stem cell division
GO:2000041	negative regulation of planar cell polarity pathway involved in axis elongation

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:108078

InterPro

IPR001134 Netrin domain
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
IPR018933 Netrin module, non-TIMP type
IPR020067 Frizzled domain

PFAM

PF01759
PF01392

PRINTS

PIRSF

SMART

SM00643
SM00063

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P97299