Version 5.4
Mus musculus Protein: Gle1
Summary
InnateDB Protein IDBP-154840.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gle1
Protein Name GLE1 RNA export mediator (yeast)
Synonyms 4933405K21Rik; AA553313; Gle1l;
Species Mus musculus
Ensembl Protein ENSMUSP00000019859
InnateDB Gene IDBG-154838 (Gle1)
Protein Structure
UniProt Annotation
Function Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus, nuclear pore complex {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. Localizes to the nuclear pore complex and nuclear envelope. Shuttling is essential for its mRNA export function (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0015031 protein transport
GO:0016973 poly(A)+ mRNA export from nucleus
Cellular Component
GO:0005615 extracellular space
GO:0005643 nuclear pore
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:1921662
InterPro IPR012476 GLE1-like
PFAM PF07817
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R322
PhosphoSite PhosphoSite-Q8R322
TrEMBL
UniProt Splice Variant
Entrez Gene 74412
UniGene Mm.459042
RefSeq NP_083199
MGI ID
MGI Symbol Gle1
OMIM
CCDS CCDS15862
HPRD
IMGT
EMBL AK016671 AK028183 AK133888 AK145748 AK150230 AK161015 AK161659 AL928926 BC026797
GenPept AAH26797 BAB30371 BAC25796 BAE21914 BAE26625 BAE29396 BAE36148 BAE36515 CAM46233

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca