InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sipa1l1

Summary

InnateDB Protein

IDBP-154954.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sipa1l1

Protein Name

signal-induced proliferation-associated 1 like 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000061014

InnateDB Gene

IDBG-154952 (Sipa1l1)

Protein Structure

UniProt Annotation

Function

Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F- actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0031532	actin cytoskeleton reorganization
GO:0032317	regulation of Rap GTPase activity
GO:0032861	activation of Rap GTPase activity
GO:0048013	ephrin receptor signaling pathway
GO:0048167	regulation of synaptic plasticity
GO:0050770	regulation of axonogenesis
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0061001	regulation of dendritic spine morphogenesis