InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dusp1

Summary

InnateDB Protein

IDBP-155236.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dusp1

Protein Name

dual specificity phosphatase 1

Synonyms

3CH134; erp; mkp-1; MKP1; Ptpn16; U19515;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025025

InnateDB Gene

IDBG-155234 (Dusp1)

Protein Structure

UniProt Annotation

Function

Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	4 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0008330	protein tyrosine/threonine phosphatase activity
GO:0016791	phosphatase activity
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0001706	endoderm formation
GO:0006470	protein dephosphorylation
GO:0009416	response to light stimulus
GO:0010033	response to organic substance
GO:0016311	dephosphorylation
GO:0032355	response to estradiol
GO:0032526	response to retinoic acid
GO:0032870	cellular response to hormone stimulus
GO:0033574	response to testosterone
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0035556	intracellular signal transduction
GO:0035970	peptidyl-threonine dephosphorylation
GO:0042542	response to hydrogen peroxide
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043407	negative regulation of MAP kinase activity
GO:0043409	negative regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)
GO:0051384	response to glucocorticoid
GO:0051447	negative regulation of meiotic cell cycle
GO:0051591	response to cAMP
GO:0051592	response to calcium ion
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0071850	mitotic cell cycle arrest
GO:0090266	regulation of mitotic cell cycle spindle assembly checkpoint
GO:2000279	negative regulation of DNA biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:105120

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR001763 Rhodanese-like domain
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
IPR020417 Atypical dual specificity phosphatase
IPR020420 Atypical dual specificity phosphatase, subfamily B
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00782
PF00581

PRINTS

PR00700
PR01764
PR01908
PR01910

PIRSF

PIRSF000939

SMART

SM00194
SM00450
SM00404
SM00195

TIGRFAMs

Post-translational Modifications

Modification

Cross-References