Mus musculus Protein: Pfn3
Summary
InnateDB Protein IDBP-155622.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pfn3
Protein Name profilin 3
Synonyms 1700012P12Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000054053
InnateDB Gene IDBG-155620 (Pfn3)
Protein Structure
UniProt Annotation
Function Binds to actin and affects the structure of the cytoskeleton. Binds to poly-L-proline, phosphatidylinositol 3- phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). Slightly reduces actin polymerization. May be involved in spermatogenesis. {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000269PubMed:18692047}.
Disease Associations
Tissue Specificity Testis specific. {ECO:0000269PubMed:11867228}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005471 ATP:ADP antiporter activity
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
GO:0015866 ADP transport
GO:0015867 ATP transport
GO:0030036 actin cytoskeleton organization
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Protein Structure and Domains
PDB ID MGI:2178800
InterPro IPR005454 Profilin, chordates
IPR005455 Profilin
PFAM PF00235
PRINTS PR01639
PR00392
PR01640
PIRSF
SMART SM00392
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DAD6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 75477
UniGene Mm.459698
RefSeq NP_083579
MGI ID
MGI Symbol Pfn3
OMIM
CCDS CCDS26545
HPRD
IMGT
EMBL AF422809 AK005930 BC048629
GenPept AAH48629 AAL65908 BAB24322