InnateDB Protein
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IDBP-155622.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pfn3
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Protein Name
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profilin 3
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Synonyms
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1700012P12Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000054053
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InnateDB Gene
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IDBG-155620 (Pfn3)
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Protein Structure
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Function |
Binds to actin and affects the structure of the cytoskeleton. Binds to poly-L-proline, phosphatidylinositol 3- phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). Slightly reduces actin polymerization. May be involved in spermatogenesis. {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000269PubMed:18692047}.
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Disease Associations |
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Tissue Specificity |
Testis specific. {ECO:0000269PubMed:11867228}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2178800
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InterPro |
IPR005454
Profilin, chordates
IPR005455
Profilin
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PFAM |
PF00235
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PRINTS |
PR01639
PR00392
PR01640
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PIRSF |
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SMART |
SM00392
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TIGRFAMs |
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Modification |
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SwissProt |
Q9DAD6
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
75477
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UniGene |
Mm.459698
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RefSeq |
NP_083579
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MGI ID |
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MGI Symbol |
Pfn3
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OMIM |
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CCDS |
CCDS26545
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HPRD |
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IMGT |
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EMBL |
AF422809
AK005930
BC048629
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GenPept |
AAH48629
AAL65908
BAB24322
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