Version 5.4
Mus musculus Protein: Slc52a2
Summary
InnateDB Protein IDBP-155658.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc52a2
Protein Name G protein-coupled receptor 172B
Synonyms 2010003P03Rik; D15Ertd747e; GPCR42; Gpr172b; mRFT1; PAR2;
Species Mus musculus
Ensembl Protein ENSMUSP00000023220
InnateDB Gene IDBG-155656 (Slc52a2)
Protein Structure
UniProt Annotation
Function Riboflavin transporter. Riboflavin transport is Na(+)- independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A) (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0032217 riboflavin transporter activity
Biological Process
GO:0032218 riboflavin transport
Cellular Component
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID MGI:1289288
InterPro IPR009357 Endogenous retrovirus receptor
PFAM PF06237
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D8F3
PhosphoSite PhosphoSite-Q9D8F3
TrEMBL
UniProt Splice Variant
Entrez Gene 52710
UniGene
RefSeq NP_083919
MGI ID
MGI Symbol Slc52a2
OMIM
CCDS CCDS27575
HPRD
IMGT
EMBL AK008081 AK029579 AK032015 AK080449 AK142597 AK152335 AK161447 BC016264
GenPept AAH16264 BAB25447 BAC26522 BAC27648 BAC37920 BAE25123 BAE31133 BAE36401

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca