InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chmp3

Summary

InnateDB Protein

IDBP-155725.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chmp3

Protein Name

charged multivesicular body protein 3

Synonyms

25.1; 4921505F14Rik; 9130011K15Rik; CGI-49; D6Ertd286e; NEDF; Vps24;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000068410

InnateDB Gene

IDBG-155723 (Chmp3)

Protein Structure

UniProt Annotation

Function

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Endosome {ECO:0000250}. Late endosome membrane {ECO:0000250}. Note=Localizes to the midbody of dividing cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in lung, testis, heart, spleen, skeletal muscle, kidney, liver and brain. {ECO:0000269PubMed:17331679}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding

Biological Process

GO:0007049	cell cycle
GO:0008333	endosome to lysosome transport
GO:0015031	protein transport
GO:0051036	regulation of endosome size
GO:0051301	cell division

Cellular Component

GO:0005769	early endosome
GO:0005829	cytosol
GO:0030496	midbody
GO:0031902	late endosome membrane

Protein Structure and Domains

PDB ID

MGI:1913950

InterPro

IPR005024 Snf7

PFAM

PF03357

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CQ10

PhosphoSite

PhosphoSite-Q9CQ10

TrEMBL

UniProt Splice Variant

Entrez Gene

66700

UniGene

Mm.487229

RefSeq

XP_006506543

MGI ID

MGI Symbol

Chmp3

OMIM

CCDS

CCDS20232

HPRD

IMGT

EMBL

AK009414 AK014818 AK016677 AK018611 AK083562 BC049964

GenPept

AAH49964 BAB26273 BAB29566 BAB30375 BAB31306 BAC38951