Version 5.4
Mus musculus Protein: Tnfsf8
Summary
InnateDB Protein IDBP-155790.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tnfsf8
Protein Name tumor necrosis factor (ligand) superfamily, member 8
Synonyms CD153; Cd30l; CD30LG;
Species Mus musculus
Ensembl Protein ENSMUSP00000030047
InnateDB Gene IDBG-155788 (Tnfsf8)
Protein Structure
UniProt Annotation
Function Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.
Subcellular Localization Membrane; Single-pass type II membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0043374 CD8-positive, alpha-beta T cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005615 extracellular space
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:88328
InterPro IPR006052 Tumour necrosis factor domain
IPR008983 Tumour necrosis factor-like domain
IPR021185 Tumour necrosis factor family protein, CD30 ligand type
PFAM PF00229
PRINTS
PIRSF PIRSF019548
SMART SM00207
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P32972
PhosphoSite PhosphoSite-
TrEMBL Q544U1
UniProt Splice Variant
Entrez Gene 21949
UniGene Mm.4664
RefSeq NP_033429
MGI ID
MGI Symbol Tnfsf8
OMIM
CCDS CCDS18264
HPRD
IMGT
EMBL AK030916 AK157270 BC117093 BC117097 CH466527 L09754
GenPept AAA74595 AAI17094 AAI17098 BAC27182 BAE34022 EDL31091

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca