Version 5.4
Homo sapiens Protein: TMEM66
Summary
InnateDB Protein IDBP-15594.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM66
Protein Name transmembrane protein 66
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000256255
InnateDB Gene IDBG-15592 (TMEM66)
Protein Structure
UniProt Annotation
Function Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)- dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. {ECO:0000269PubMed:22464749}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:22464749}; Single-pass type I membrane protein {ECO:0000269PubMed:22464749}. Note=Translocates to the endoplasmic reticulum-plasma membrane (ER-PM) region in a STIM1- dependent manner following cytosolic Ca(2+) elevation.Isoform 2: Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Highly expressed in macrophages. {ECO:0000269Ref.2}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015279 store-operated calcium channel activity
Biological Process
GO:0070588 calcium ion transmembrane transport
GO:2001256 regulation of store-operated calcium entry
Cellular Component
GO:0030176 integral component of endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID
InterPro IPR009567 Protein of unknown function DUF1183, TMEM66
PFAM PF06682
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96BY9
PhosphoSite PhosphoSite-Q96BY9
TrEMBL E5RHW0
UniProt Splice Variant
Entrez Gene 51669
UniGene Hs.521487
RefSeq NP_057211
HUGO HGNC:28789
OMIM 614768
CCDS CCDS6074
HPRD 08651
IMGT
EMBL AB028926 AC044849 AF078855 AF100748 AF490252 AK075340 AK222632 AK295360 AK315956 AY359104 BC015012 CH471080 JQ348891 JQ348892
GenPept AAD43012 AAD44487 AAH15012 AAO85460 AAQ89462 AEZ06361 AEZ06362 BAB82465 BAD96352 BAG52116 BAH12043 BAH14327 EAW63471 EAW63472 EAW63474

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca