InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sgol2

Summary

InnateDB Protein

IDBP-155966.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sgol2

Protein Name

shugoshin-like 2 (S. pombe)

Synonyms

1110007N04Rik; 4932411A20Rik; 5730576N04Rik; AU018846; AV008062; D1Ertd8e; Tripin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027202

InnateDB Gene

IDBG-155964 (Sgol2)

Protein Structure

UniProt Annotation

Function

Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation. Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. {ECO:0000269PubMed:18084284, ECO:0000269PubMed:18765791}.

Subcellular Localization

Nucleus {ECO:0000250}. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Centromeric localization requires the presence of BUB1 and AUKRB. During meiosis I, accumulates at centromeres during diplotene, and colocalizes differentially with the cohesin subunits RAD21 and REC8 at metaphase I centromeres. SGO2 and RAD21 change their relative distributions during telophase I when sister-kinetochore association is lost. During meiosis II, it shows a striking tension-dependent redistribution within centromeres throughout chromosome congression during prometaphase II, as it does during mitosis.

Disease Associations

Tissue Specificity

Ubiquitously expressed in proliferating cells. Highly expressed in the testis and oocytes. {ECO:0000269PubMed:18084284}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007140	male meiosis
GO:0007143	female meiotic division
GO:0008104	protein localization
GO:0051754	meiotic sister chromatid cohesion, centromeric
GO:2000711	positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000779	condensed chromosome, centromeric region
GO:0000780	condensed nuclear chromosome, centromeric region