Version 5.4
Mus musculus Protein: Bak1
Summary
InnateDB Protein IDBP-156211.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Bak1
Protein Name BCL2-antagonist/killer 1
Synonyms Bak; N-Bak; N-BAK1;
Species Mus musculus
Ensembl Protein ENSMUSP00000025034
InnateDB Gene IDBG-156207 (Bak1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001776 leukocyte homeostasis
GO:0001782 B cell homeostasis
GO:0001783 B cell apoptotic process
GO:0001974 blood vessel remodeling
GO:0002262 myeloid cell homeostasis
GO:0002352 B cell negative selection
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008053 mitochondrial fusion
GO:0008283 cell proliferation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0009620 response to fungus
GO:0010046 response to mycotoxin
GO:0010332 response to gamma radiation
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0035108 limb morphogenesis
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0044346 fibroblast apoptotic process
GO:0048597 post-embryonic camera-type eye morphogenesis
GO:0048872 homeostasis of number of cells
GO:0051726 regulation of cell cycle
GO:0060068 vagina development
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070242 thymocyte apoptotic process
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:1902262 apoptotic process involved in patterning of blood vessels
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0031966 mitochondrial membrane
Protein Structure and Domains
PDB ID MGI:1097161
InterPro IPR002475 Bcl2-like
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q91ZT2
UniProt Splice Variant
Entrez Gene 12018
UniGene Mm.2443
RefSeq
MGI ID
MGI Symbol Bak1
OMIM
CCDS
HPRD
IMGT
EMBL AC132404 AF402616 AF402617 BC057589
GenPept AAH57589 AAL01875 AAL01876

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca