InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sap30

Summary

InnateDB Protein

IDBP-156214.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sap30

Protein Name

sin3 associated polypeptide

Synonyms

30kDa;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034022

InnateDB Gene

IDBG-156212 (Sap30)

Protein Structure

UniProt Annotation

Function

Involved in the functional recruitment of the Sin3- histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N- CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones. {ECO:0000250UniProtKB:O75446, ECO:0000269PubMed:9702189}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0035914	skeletal muscle cell differentiation