InnateDB Protein
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IDBP-156237.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Hmgb2
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Protein Name
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high mobility group box 2
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Synonyms
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C80539; HMG-2; Hmg2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000065940
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InnateDB Gene
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IDBG-156235 (Hmgb2)
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Protein Structure
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Function |
DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). {ECO:0000269PubMed:9184213}.
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Subcellular Localization |
Nucleus. Chromosome.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated |
Total |
15
[view]
|
Protein-Protein |
15
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
21 [view]
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Molecular Function |
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Biological Process |
GO:0001938
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positive regulation of endothelial cell proliferation
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GO:0006288
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base-excision repair, DNA ligation
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0007283
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spermatogenesis
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GO:0007289
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spermatid nucleus differentiation
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GO:0008584
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male gonad development
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GO:0032075
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positive regulation of nuclease activity
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GO:0043388
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positive regulation of DNA binding
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GO:0045648
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positive regulation of erythrocyte differentiation
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GO:0045654
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positive regulation of megakaryocyte differentiation
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0048545
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response to steroid hormone
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GO:0050918
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positive chemotaxis
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GO:0060326
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cell chemotaxis
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GO:0071222
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cellular response to lipopolysaccharide
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GO:1902042
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negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
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Cellular Component |
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PDB ID |
MGI:96157
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InterPro |
IPR009071
High mobility group box domain
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PFAM |
PF00505
PF09011
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PRINTS |
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PIRSF |
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SMART |
SM00398
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TIGRFAMs |
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Modification |
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SwissProt |
P30681
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PhosphoSite |
PhosphoSite-P30681
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
97165
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UniGene |
Mm.490424
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RefSeq |
NP_032278
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MGI ID |
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MGI Symbol |
Hmgb2
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OMIM |
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CCDS |
CCDS40343
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HPRD |
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IMGT |
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EMBL |
AF267733
AK003773
AK008443
AK012568
AK135296
AK135297
AK146212
BC002050
BC046759
BC083108
X67668
Z46757
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GenPept |
AAG36939
AAH02050
AAH46759
AAH83108
BAB22988
BAB25672
BAB28323
BAE22481
BAE22482
BAE26982
CAA47900
CAA86727
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