Version 5.4
Mus musculus Protein: Lage3
Summary
InnateDB Protein IDBP-156246.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lage3
Protein Name L antigen family, member 3
Synonyms 1110049G11Rik; Eso3; Itba2;
Species Mus musculus
Ensembl Protein ENSMUSP00000015433
InnateDB Gene IDBG-156244 (Lage3)
Protein Structure
UniProt Annotation
Function Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008033 tRNA processing
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1913442
InterPro IPR015419 EKC/KEOPS complex, subunit Pcc1
PFAM PF09341
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CR70
PhosphoSite PhosphoSite-Q9CR70
TrEMBL J3JS94
UniProt Splice Variant
Entrez Gene 66192
UniGene Mm.21705
RefSeq NP_079686
MGI ID
MGI Symbol Lage3
OMIM
CCDS CCDS30229
HPRD
IMGT
EMBL AK002539 AK004210 AL807376
GenPept BAB22174 BAB23222 CAM24349

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca