InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: G6pdx

Summary

InnateDB Protein

IDBP-156376.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

G6pdx

Protein Name

glucose-6-phosphate dehydrogenase X-linked

Synonyms

G28A; G6pd; Gpdx;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000004327

InnateDB Gene

IDBG-156374 (G6pdx)

Protein Structure

UniProt Annotation

Function

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004345	glucose-6-phosphate dehydrogenase activity
GO:0042803	protein homodimerization activity
GO:0050661	NADP binding

Biological Process

GO:0001816	cytokine production
GO:0001998	angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0002033	vasodilation by angiotensin involved in regulation of systemic arterial blood pressure
GO:0006006	glucose metabolic process
GO:0006098	pentose-phosphate shunt
GO:0006739	NADP metabolic process
GO:0006741	NADP biosynthetic process
GO:0006749	glutathione metabolic process
GO:0006979	response to oxidative stress
GO:0019322	pentose biosynthetic process
GO:0032613	interleukin-10 production
GO:0032615	interleukin-12 production
GO:0040014	regulation of multicellular organism growth
GO:0048821	erythrocyte development
GO:0051156	glucose 6-phosphate metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

Protein Structure and Domains

PDB ID

MGI:105979

InterPro

IPR001282 Glucose-6-phosphate dehydrogenase
IPR022674 Glucose-6-phosphate dehydrogenase, NAD-binding
IPR022675 Glucose-6-phosphate dehydrogenase, C-terminal

PFAM

PF00479
PF02781

PRINTS

PR00079

PIRSF

PIRSF000110

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt