InnateDB Protein
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IDBP-156686.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ppapdc2
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Protein Name
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phosphatidic acid phosphatase type 2 domain containing 2
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Synonyms
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4932443D16Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000047776
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InnateDB Gene
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IDBG-156684 (Ppapdc2)
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Protein Structure
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Function |
Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid (By similarity). {ECO:0000250}.
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Subcellular Localization |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1921661
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InterPro |
IPR000326
Phosphatidic acid phosphatase type 2/haloperoxidase
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PFAM |
PF01569
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PRINTS |
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PIRSF |
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SMART |
SM00014
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TIGRFAMs |
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Modification |
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SwissProt |
Q9D4F2
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PhosphoSite |
PhosphoSite-Q9D4F2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
74411
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UniGene |
Mm.441887
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RefSeq |
NP_083198
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MGI ID |
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MGI Symbol |
Ppapdc2
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OMIM |
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CCDS |
CCDS29728
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HPRD |
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IMGT |
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EMBL |
AK016572
BC052412
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GenPept |
AAH52412
BAB30313
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