InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vsx2

Summary

InnateDB Protein

IDBP-156856.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vsx2

Protein Name

visual system homeobox 2

Synonyms

Chx10; Hox-10; Hox10; or;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021665

InnateDB Gene

IDBG-156854 (Vsx2)

Protein Structure

UniProt Annotation

Function

Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells.

Subcellular Localization

Nucleus.

Disease Associations

Note=Defects in Vsx2 are the cause of ocular retardation (OR(J)), a mouse disease characterized by microphthalmia, progressive destruction of the retina, and absence of the optic nerve. The OR(J) mutation is due to an OCHR (STOP) mutation.

Tissue Specificity

Expressed throughout the anterior optic vesicle and all neuroblasts of the optic cup. In the mature retina Is restricted to the inner nuclear layer, in which its expression decreases from the outer to the inner margin. Also detected in regions of the developing thalamus, hindbrain, and ventral spinal cord.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0043010	camera-type eye development
GO:0045165	cell fate commitment
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060040	retinal bipolar neuron differentiation
GO:0060042	retina morphogenesis in camera-type eye