Version 5.4
| Mus musculus Protein: Kirrel | |||||||||||
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| Summary | |||||||||||
| InnateDB Protein | IDBP-156902.6 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | Kirrel | ||||||||||
| Protein Name | kin of IRRE like (Drosophila) | ||||||||||
| Synonyms | |||||||||||
| Species | Mus musculus | ||||||||||
| Ensembl Protein | ENSMUSP00000043756 | ||||||||||
| InnateDB Gene | IDBG-156900 (Kirrel) | ||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||
| Function | Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. {ECO:0000269PubMed:11416156}. | ||||||||||
| Subcellular Localization | Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Predominantly located at podocyte slit diaphragm. | ||||||||||
| Disease Associations | |||||||||||
| Tissue Specificity | Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli. {ECO:0000269PubMed:12865409}. | ||||||||||
| Comments | |||||||||||
| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||
| PDB ID | MGI:1891396 | ||||||||||
| InterPro |
IPR003598
Immunoglobulin subtype 2 IPR003599 Immunoglobulin subtype IPR007110 Immunoglobulin-like domain IPR013098 Immunoglobulin I-set IPR013106 Immunoglobulin V-set domain IPR013151 Immunoglobulin IPR013162 CD80-like, immunoglobulin C2-set |
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| PFAM |
PF07679
PF07686 PF00047 PF08205 |
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| PRINTS | |||||||||||
| PIRSF | |||||||||||
| SMART |
SM00408
SM00409 |
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| TIGRFAMs | |||||||||||
| Post-translational Modifications | |||||||||||
| Modification | |||||||||||
| Cross-References | |||||||||||
| SwissProt | Q80W68 | ||||||||||
| PhosphoSite | PhosphoSite-Q80W68 | ||||||||||
| TrEMBL | |||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 170643 | ||||||||||
| UniGene | Mm.89552 | ||||||||||
| RefSeq | |||||||||||
| MGI ID | 4OFD | ||||||||||
| MGI Symbol | Kirrel | ||||||||||
| OMIM | |||||||||||
| CCDS | |||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | AF480411 AY017368 AY243095 BC023765 | ||||||||||
| GenPept | AAH23765 AAK00528 AAN73043 AAO91769 | ||||||||||