InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sftpb

Summary

InnateDB Protein

IDBP-156919.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sftpb

Protein Name

surfactant associated protein B

Synonyms

AI562151; SF-B; Sftp-3; Sftp3; SP-B;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000066805

InnateDB Gene

IDBG-156917 (Sftpb)

Protein Structure

UniProt Annotation

Function

Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.

Subcellular Localization

Secreted, extracellular space, surface film.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0006629	lipid metabolic process
GO:0006665	sphingolipid metabolic process
GO:0007585	respiratory gaseous exchange

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005764	lysosome

Protein Structure and Domains

PDB ID

MGI:109516

InterPro

IPR003119 Saposin type A
IPR007856 Saposin-like type B, 1
IPR008138 Saposin-like type B, 2
IPR008139 Saposin B
IPR008373 Saposin
IPR011001 Saposin-like

PFAM

PF02199
PF05184
PF03489

PRINTS

PR01797

PIRSF

SMART

SM00162
SM00741

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt