InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tor1b

Summary

InnateDB Protein

IDBP-157098.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tor1b

Protein Name

torsin family 1, member B

Synonyms

2610016F05Rik; DQ1; torsinB;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028199

InnateDB Gene

IDBG-157094 (Tor1b)

Protein Structure

UniProt Annotation

Function

May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Plays a role in non-neural cells nuclear envelope and endoplasmic reticulum integrity. May have a redundant function with TOR1A in non-neural tissues. {ECO:0000269PubMed:20457914}.

Subcellular Localization

Endoplasmic reticulum lumen. Nucleus membrane.

Disease Associations

Tissue Specificity

Highly expressed in liver and muscle; lower expression levels are observed in brain (at ptrotein level). {ECO:0000269PubMed:20015956}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0007029	endoplasmic reticulum organization
GO:0051085	chaperone mediated protein folding requiring cofactor
GO:0051260	protein homooligomerization
GO:0071763	nuclear membrane organization

Cellular Component

GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0031965	nuclear membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1353605

InterPro

IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR010448 Torsin
IPR017378 Torsin, subgroup
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00004
PF07724
PF13304
PF06309

PRINTS

PIRSF

PIRSF038079

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt