Version 5.4
Mus musculus Protein: Parp14
Summary
InnateDB Protein IDBP-157341.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Parp14
Protein Name poly (ADP-ribose) polymerase family, member 14
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000037657
InnateDB Gene IDBG-157339 (Parp14)
Protein Structure
UniProt Annotation
Function Has ADP-ribosyltransferase activity (By similarity). Enhances STAT6-dependent transcription. {ECO:0000250, ECO:0000269PubMed:16537510}.
Subcellular Localization Nucleus {ECO:0000269PubMed:16537510}. Cytoplasm {ECO:0000269PubMed:16537510}. Note=In steady state cells the protein is mostly nuclear. A minor proportion is detected in the cytoplasm.
Disease Associations
Tissue Specificity Weakly expressed in the thymus during development and in adulthood. {ECO:0000269PubMed:18069692}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:1919489
InterPro IPR002589 Macro domain
IPR004170 WWE domain
IPR012317 Poly(ADP-ribose) polymerase, catalytic domain
PFAM PF01661
PF02825
PF00644
PRINTS
PIRSF
SMART SM00506
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2EMV9
PhosphoSite PhosphoSite-Q2EMV9
TrEMBL
UniProt Splice Variant
Entrez Gene 547253
UniGene Mm.416099
RefSeq NP_001034619
MGI ID 1X4R
MGI Symbol Parp14
OMIM
CCDS CCDS28143
HPRD
IMGT
EMBL AC129574 AK089685 AK220263 BC021340 DQ372930
GenPept AAH21340 ABD16173 BAC40943 BAD90188

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca