InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PSMC1

Summary

InnateDB Protein

IDBP-15763.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PSMC1

Protein Name

proteasome (prosome, macropain) 26S subunit, ATPase, 1

Synonyms

P26S4; p56; S4;

Species

Homo sapiens

Ensembl Protein

ENSP00000261303

InnateDB Gene

IDBG-15761 (PSMC1)

Protein Structure

UniProt Annotation

Function

The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 119 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	119 [view]
Protein-Protein	119 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008233	peptidase activity
GO:0009378	four-way junction helicase activity
GO:0016787	hydrolase activity
GO:0016887	ATPase activity
GO:0017025	TBP-class protein binding
GO:0017111	nucleoside-triphosphatase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000209	protein polyubiquitination
GO:0000278	mitotic cell cycle
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006508	proteolysis
GO:0006521	regulation of cellular amino acid metabolic process
GO:0006915	apoptotic process
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0030163	protein catabolic process
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0044281	small molecule metabolic process
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

Cellular Component

GO:0000502	proteasome complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005838	proteasome regulatory particle
GO:0016020	membrane
GO:0022624	proteasome accessory complex

Protein Structure and Domains

PDB ID

InterPro

IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR005937 26S proteasome subunit P45
IPR008533 Domain of unknown function DUF815
IPR008824 DNA helicase, Holliday junction RuvB type, N-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00004
PF07724
PF13304
PF05673
PF05496

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P62191