InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Scube3

Summary

InnateDB Protein

IDBP-157672.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scube3

Protein Name

signal peptide, CUB domain, EGF-like 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038366

InnateDB Gene

IDBG-157668 (Scube3)

Protein Structure

UniProt Annotation

Function

Binds to TGFBR2 and activates TGFB signaling. {ECO:0000250}.

Subcellular Localization

Secreted. Cell surface {ECO:0000250UniProtKB:Q8IX30}.

Disease Associations

Tissue Specificity

Highly expressed in femur and humerus with little or no expression in non-bone tissues. {ECO:0000269PubMed:15234972}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0051260	protein homooligomerization
GO:0051291	protein heterooligomerization

Cellular Component

GO:0005576	extracellular region
GO:0009986	cell surface

Protein Structure and Domains

PDB ID

MGI:3045253

InterPro

IPR000742 Epidermal growth factor-like domain
IPR000859 CUB domain
IPR001881 EGF-like calcium-binding domain
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like

PFAM

PF00008
PF00431
PF07645
PF07699

PRINTS

PIRSF

SMART

SM00181
SM00042
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q66PY1