InnateDB Protein
|
IDBP-157709.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Ncs1
|
Protein Name
|
neuronal calcium sensor 1
|
Synonyms
|
9430075O15Rik; A730032G13Rik; AI836659; Freq; Mfreq; NCS-1;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000000199
|
InnateDB Gene
|
IDBG-157707 (Ncs1)
|
Protein Structure
|
|
Function |
Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Golgi apparatus, Golgi stack membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions (By similarity). {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
8 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0010975
|
regulation of neuron projection development
|
GO:0045921
|
positive regulation of exocytosis
|
GO:0048015
|
phosphatidylinositol-mediated signaling
|
GO:0050806
|
positive regulation of synaptic transmission
|
GO:0070588
|
calcium ion transmembrane transport
|
|
Cellular Component |
|
PDB ID |
MGI:109166
|
InterPro |
IPR002048
EF-hand domain
|
PFAM |
PF00036
PF13202
PF13405
|
PRINTS |
|
PIRSF |
|
SMART |
SM00054
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8BNY6
|
PhosphoSite |
PhosphoSite-Q8BNY6
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
14299
|
UniGene |
Mm.487857
|
RefSeq |
NP_062655
|
MGI ID |
|
MGI Symbol |
Ncs1
|
OMIM |
|
CCDS |
CCDS15896
|
HPRD |
|
IMGT |
|
EMBL |
AF020184
AK079136
AL732572
BC059825
|
GenPept |
AAD01642
AAH59825
BAC37557
CAM21076
|
|
|