InnateDB Protein
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IDBP-157715.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Fam162a
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Protein Name
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family with sequence similarity 162, member A
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Synonyms
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2310056P07Rik; HGTD-P;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000004057
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InnateDB Gene
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IDBG-157713 (Fam162a)
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Protein Structure
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Function |
Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly. {ECO:0000269PubMed:15082785, ECO:0000269PubMed:17316997}.
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Subcellular Localization |
Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Mitochondrion {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
14 [view]
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Molecular Function |
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Biological Process |
GO:0006919
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activation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0006927
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transformed cell apoptotic process
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GO:0043065
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positive regulation of apoptotic process
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GO:0051402
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neuron apoptotic process
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GO:0071456
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cellular response to hypoxia
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GO:0090200
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positive regulation of release of cytochrome c from mitochondria
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Cellular Component |
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PDB ID |
MGI:1917436
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InterPro |
IPR009432
Protein of unknown function DUF1075
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PFAM |
PF06388
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9D6U8
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PhosphoSite |
PhosphoSite-Q9D6U8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
70186
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UniGene |
Mm.212991
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RefSeq |
NP_081618
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MGI ID |
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MGI Symbol |
Fam162a
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OMIM |
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CCDS |
CCDS28146
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HPRD |
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IMGT |
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EMBL |
AK009946
BC010826
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GenPept |
AAH10826
BAB26601
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