InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mpp4

Summary

InnateDB Protein

IDBP-157989.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mpp4

Protein Name

membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000077914

InnateDB Gene

IDBG-252103 (Mpp4)

Protein Structure

UniProt Annotation

Function

May play a role in retinal photoreceptors development. {ECO:0000269PubMed:12859944}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12859944, ECO:0000269PubMed:15558731}. Note=Localized at photoreceptor synaptic terminals in retina. Localized in rod and cone photoreceptors at the plasma membrane and at membranes of intracellular vesicles around the subapical region (SAR) and adherens junction, and in the outer plexiform layer (OPL).

Disease Associations

Tissue Specificity

Detected in the retina (at protein level). Highly enriched in the retina where it is mainly expressed by rod photoreceptors; detected in the inner segment of the photoreceptor layer and in the outer nuclear layer. Also detected at much lower levels in pineal gland, cerebellum, cortex, hippocampus, olfactory bulb, heart, liver and spleen. Expressed in the CA1-CA3 regions of pyramidal cell layers and in the granule cell layer of dentate gyrus in the hippocampus. In the cerebellum, expressed in Purkinje cells and throughout the granule cell layer. In the olfactory bulb, expressed in mitral cells. {ECO:0000269PubMed:12127943, ECO:0000269PubMed:12384283, ECO:0000269PubMed:12859944, ECO:0000269PubMed:15558731}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0035418

protein localization to synapse

Cellular Component

GO:0005737	cytoplasm
GO:0042734	presynaptic membrane

Protein Structure and Domains

PDB ID

MGI:2386681

InterPro

IPR001452 SH3 domain
IPR001478 PDZ domain
IPR004172 L27
IPR008144 Guanylate kinase-like
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR011511 Variant SH3 domain
IPR014775 L27, C-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM