Version 5.4
Mus musculus Protein: Mbd1
Summary
InnateDB Protein IDBP-158062.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mbd1
Protein Name methyl-CpG binding domain protein 1
Synonyms Cxxc3; PCM1;
Species Mus musculus
Ensembl Protein ENSMUSP00000095137
InnateDB Gene IDBG-158060 (Mbd1)
Protein Structure
UniProt Annotation
Function Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 can also repress transcription from unmethylated promoters. {ECO:0000269PubMed:15060159, ECO:0000269PubMed:9774669}.
Subcellular Localization Nucleus. Nucleus matrix. Nucleus speckle. Chromosome. Note=Nuclear, in a punctate pattern. Associated with euchromatic regions of the chromosomes. Colocalizes with the Ten-1 ICD form of TENM1 in foci associated with the nuclear matrix.
Disease Associations
Tissue Specificity Highly expressed in kidney, liver and brain. Detected at lower levels in heart, lung, skeletal muscle, spleen and testis. {ECO:0000269PubMed:9774669}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006306 DNA methylation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0000785 chromatin
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016363 nuclear matrix
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID MGI:1333811
InterPro IPR001739 Methyl-CpG DNA binding
IPR002857 Zinc finger, CXXC-type
IPR016177 DNA-binding domain
PFAM PF01429
PF02008
PRINTS
PIRSF
SMART SM00391
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z2E2
PhosphoSite PhosphoSite-Q9Z2E2
TrEMBL
UniProt Splice Variant
Entrez Gene 17190
UniGene
RefSeq NP_038622
MGI ID
MGI Symbol Mbd1
OMIM
CCDS CCDS50321
HPRD
IMGT
EMBL AF072240 AF120978 AK004624 AK032535 AK156401 AK166042 BC069837
GenPept AAC68869 AAD48908 AAH69837 BAB23419 BAC27914 BAE33700 BAE38538

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca