InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd86

Summary

InnateDB Protein

IDBP-158075.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd86

Protein Name

CD86 antigen

Synonyms

B7; B7-2; B7.2; B70; Cd28l2; CLS1; ETC-1; Ly-58; Ly58; MB7; MB7-2; TS/A-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000087047

InnateDB Gene

IDBG-158071 (Cd86)

Protein Structure

UniProt Annotation

Function

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed on activated B-cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	1 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding

Biological Process

GO:0001878	response to yeast
GO:0002224	toll-like receptor signaling pathway
GO:0002309	T cell proliferation involved in immune response
GO:0002668	negative regulation of T cell anergy
GO:0007568	aging
GO:0032496	response to lipopolysaccharide
GO:0034341	response to interferon-gamma
GO:0042102	positive regulation of T cell proliferation
GO:0042104	positive regulation of activated T cell proliferation
GO:0042113	B cell activation
GO:0042493	response to drug
GO:0043011	myeloid dendritic cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0051607	defense response to virus
GO:0071222	cellular response to lipopolysaccharide
GO:0071248	cellular response to metal ion
GO:0071345	cellular response to cytokine stimulus

Cellular Component

GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome