InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IGFBP3

Summary

InnateDB Protein

IDBP-15811.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IGFBP3

Protein Name

insulin-like growth factor binding protein 3

Synonyms

BP-53; IBP3;

Species

Homo sapiens

Ensembl Protein

ENSP00000275521

InnateDB Gene

IDBG-15809 (IGFBP3)

Protein Structure

UniProt Annotation

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. {ECO:0000269PubMed:20353938}.

Subcellular Localization

Secreted {ECO:0000269PubMed:20353938}.

Disease Associations

Tissue Specificity

Expressed by most tissues. Present in plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.

Experimentally validated
Total	32 [view]
Protein-Protein	27 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding
GO:0008160	protein tyrosine phosphatase activator activity
GO:0031994	insulin-like growth factor I binding
GO:0046872	metal ion binding

Biological Process

GO:0001558	regulation of cell growth
GO:0001933	negative regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0008285	negative regulation of cell proliferation
GO:0009968	negative regulation of signal transduction
GO:0014912	negative regulation of smooth muscle cell migration
GO:0043065	positive regulation of apoptotic process
GO:0043085	positive regulation of catalytic activity
GO:0044267	cellular protein metabolic process
GO:0045663	positive regulation of myoblast differentiation
GO:0048662	negative regulation of smooth muscle cell proliferation

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0016942	insulin-like growth factor binding protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000716 Thyroglobulin type-1
IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR012211 Insulin-like growth factor binding protein 3
IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata

PFAM

PF00086
PF00219

PRINTS

PR01979
PR01976

PIRSF

SMART

SM00211
SM00121

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt