InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myh9

Summary

InnateDB Protein

IDBP-158165.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myh9

Protein Name

myosin, heavy polypeptide 9, non-muscle

Synonyms

Fltn; Myhn-1; Myhn1; NMHCIIA; NMMHC-A; NMMHC-IIA; TU72.6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000016771

InnateDB Gene

IDBG-158163 (Myh9)

Protein Structure

UniProt Annotation

Function

During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (By similarity). Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250, ECO:0000269PubMed:19401332}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:19401332}. Cytoplasm, cell cortex {ECO:0000269PubMed:19401332}. Note=Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 92 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	92 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0000166	nucleotide binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003774	motor activity
GO:0003779	actin binding
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0030898	actin-dependent ATPase activity
GO:0042803	protein homodimerization activity
GO:0043495	protein anchor
GO:0043531	ADP binding
GO:0044822	poly(A) RNA binding
GO:0051015	actin filament binding

Biological Process

GO:0000212	meiotic spindle organization
GO:0000904	cell morphogenesis involved in differentiation
GO:0000910	cytokinesis
GO:0001525	angiogenesis
GO:0001701	in utero embryonic development
GO:0001768	establishment of T cell polarity
GO:0006200	ATP catabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006509	membrane protein ectodomain proteolysis
GO:0006928	cellular component movement
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007520	myoblast fusion
GO:0008360	regulation of cell shape
GO:0015031	protein transport
GO:0016337	single organismal cell-cell adhesion
GO:0030048	actin filament-based movement
GO:0030220	platelet formation
GO:0030224	monocyte differentiation
GO:0031032	actomyosin structure organization
GO:0031532	actin cytoskeleton reorganization
GO:0032796	uropod organization
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043534	blood vessel endothelial cell migration
GO:0051295	establishment of meiotic spindle localization

Cellular Component

GO:0001725	stress fiber
GO:0001726	ruffle
GO:0001772	immunological synapse
GO:0001931	uropod
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005826	actomyosin contractile ring
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005913	cell-cell adherens junction
GO:0005938	cell cortex
GO:0008180	COP9 signalosome
GO:0008305	integrin complex
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0016459	myosin complex
GO:0016460	myosin II complex
GO:0030863	cortical cytoskeleton
GO:0031252	cell leading edge
GO:0031594	neuromuscular junction
GO:0032154	cleavage furrow
GO:0042641	actomyosin
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome
GO:0097513	myosin II filament

Protein Structure and Domains

PDB ID

MGI:107717

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR000533 Tropomyosin
IPR001609 Myosin head, motor domain
IPR002928 Myosin tail
IPR004009 Myosin, N-terminal, SH3-like
IPR008989 Myosin S1 fragment, N-terminal
IPR009053 Prefoldin
IPR010978 tRNA-binding arm
IPR015988 STAT transcription factor, coiled coil
IPR016137 Regulator of G protein signalling superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00261
PF12718
PF00063
PF01576
PF02736

PRINTS

PR00194
PR00193

PIRSF

SMART

SM00015
SM00242
SM00315

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt