InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tulp1

Summary

InnateDB Protein

IDBP-158411.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tulp1

Protein Name

tubby like protein 1

Synonyms

Tulp1l;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000049070

InnateDB Gene

IDBG-158409 (Tulp1)

Protein Structure

UniProt Annotation

Function

Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long- term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells. Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5- phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5- bisphosphate, phosphatidylserine and phosphatidic acid (in vitro) (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. {ECO:0000250, ECO:0000269PubMed:11481257, ECO:0000269PubMed:17525220, ECO:0000269PubMed:19218615, ECO:0000269PubMed:19837063}.

Subcellular Localization

Cytoplasm. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Secreted. Cell junction, synapse. Note=Detected at synapses between photoreceptor cells and second-order neurons. Does not have a cleavable signal peptide and is secreted by an alternative pathway.

Disease Associations

Tissue Specificity

Retina specific. Detected in the outer plexiform layer in photoreceptor cells (at protein level). {ECO:0000269PubMed:19218615}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0008020	G-protein coupled photoreceptor activity
GO:0051015	actin filament binding

Biological Process

GO:0001895	retina homeostasis
GO:0006909	phagocytosis
GO:0007601	visual perception
GO:0007602	phototransduction
GO:0009584	detection of visible light
GO:0016358	dendrite development
GO:0042462	eye photoreceptor cell development
GO:0045494	photoreceptor cell maintenance
GO:0050766	positive regulation of phagocytosis
GO:0050908	detection of light stimulus involved in visual perception
GO:0060041	retina development in camera-type eye

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0001917	photoreceptor inner segment
GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0030054	cell junction
GO:0042995	cell projection
GO:0045202	synapse