InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lrrtm1

Summary

InnateDB Protein

IDBP-158419.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrrtm1

Protein Name

leucine rich repeat transmembrane neuronal 1

Synonyms

4632401D06Rik; AW125451;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020400

InnateDB Gene

IDBG-158417 (Lrrtm1)

Protein Structure

UniProt Annotation

Function

Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Accumulates extensively in the endoplasmic reticulum of transfected nonneuronal cells. {ECO:0000269PubMed:17667961, ECO:0000269Ref.5}.

Disease Associations

Tissue Specificity

Expressed predominantly in the nervous system by postmitotic neurons, but also in some non-neuronal tissues. In adult brain expression is most prominent in the forebraain, particularly in the thalamus and in the cortical areas including hippocampus, piriform and posterior cingulate. {ECO:0000269PubMed:12676565, ECO:0000269PubMed:17667961}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0002091	negative regulation of receptor internalization
GO:0007626	locomotory behavior
GO:0035418	protein localization to synapse
GO:0035640	exploration behavior
GO:0050808	synapse organization
GO:0060291	long-term synaptic potentiation

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0030426	growth cone
GO:0045211	postsynaptic membrane
GO:0060076	excitatory synapse