Version 5.4
Mus musculus Protein: Man2b2
Summary
InnateDB Protein IDBP-158483.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Man2b2
Protein Name mannosidase 2, alpha B2
Synonyms mKIAA0935;
Species Mus musculus
Ensembl Protein ENSMUSP00000031002
InnateDB Gene IDBG-158481 (Man2b2)
Protein Structure
UniProt Annotation
Function Plays an important role in the early step of spermatogenesis.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Mainly expressed in the narrow region between the caput and corpus epididymis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004559 alpha-mannosidase activity
GO:0008270 zinc ion binding
GO:0015923 mannosidase activity
GO:0030246 carbohydrate binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006013 mannose metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1195262
InterPro IPR000602 Glycoside hydrolase family 38, N-terminal domain
IPR011013 Galactose mutarotase-like domain
IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
IPR011682 Glycosyl hydrolase family 38, C-terminal
IPR015341 Glycoside hydrolase, family 38, central domain
IPR028995 Glycoside hydrolase, families 57/38, central domain
PFAM PF01074
PF07748
PF09261
PRINTS
PIRSF
SMART SM00872
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O54782
PhosphoSite PhosphoSite-O54782
TrEMBL Q3U875
UniProt Splice Variant
Entrez Gene 17160
UniGene Mm.761
RefSeq NP_032576
MGI ID
MGI Symbol Man2b2
OMIM
CCDS CCDS19243
HPRD
IMGT
EMBL AB006458 AB083124 AK004900 AK040388 AK151873 AK152349 AK173067 BC066211
GenPept AAH66211 BAA24266 BAB23655 BAC30580 BAC53862 BAD32345 BAE30761 BAE31143

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca