InnateDB Protein
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IDBP-158629.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Psme4
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Protein Name
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proteasome (prosome, macropain) activator subunit 4
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Synonyms
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AA409398; AU041366; mKIAA0077; TEMO;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000045460
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InnateDB Gene
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IDBG-158627 (Psme4)
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Protein Structure
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Function |
Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks. {ECO:0000269PubMed:16581775, ECO:0000269PubMed:23706739}.
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Subcellular Localization |
Cytoplasm, cytosol. Nucleus. Nucleus speckle {ECO:0000250}. Note=Found in nuclear foci following treatment with ionizing radiation, but not with ultraviolet irradiation or H(2)O(2). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Broadly expressed. Present in heart (at protein level). {ECO:0000269PubMed:12093752, ECO:0000269PubMed:16857966}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
GO:0006281
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DNA repair
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GO:0006974
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cellular response to DNA damage stimulus
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GO:0007275
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multicellular organismal development
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GO:0010499
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proteasomal ubiquitin-independent protein catabolic process
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GO:0010952
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positive regulation of peptidase activity
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GO:0035093
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spermatogenesis, exchange of chromosomal proteins
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Cellular Component |
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PDB ID |
MGI:2143994
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InterPro |
IPR016024
Armadillo-type fold
IPR021843
Protein of unknown function DUF3437
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PFAM |
PF11919
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5SSW2
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PhosphoSite |
PhosphoSite-Q5SSW2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
103554
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UniGene |
Mm.481953
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RefSeq |
NP_598774
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MGI ID |
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MGI Symbol |
Psme4
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OMIM |
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CCDS |
CCDS36124
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HPRD |
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IMGT |
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EMBL |
AF296169
AK129049
AK131932
AK169447
AL662891
BC004575
BC031174
BC054364
BC141381
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GenPept |
AAG09060
AAH04575
AAH31174
AAH54364
AAI41382
BAC97859
BAE20881
BAE41181
CAI24530
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