InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ift27

Summary

InnateDB Protein

IDBP-158666.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ift27

Protein Name

intraflagellar transport 27 homolog (Chlamydomonas)

Synonyms

2600013G09Rik; Rabl4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000016781

InnateDB Gene

IDBG-158664 (Ift27)

Protein Structure

UniProt Annotation

Function

Small GTPase-like component of the intraflagellar transport (IFT) complex B. Forms a subcomplex within the IFT complex B with IFT25 (By similarity). {ECO:0000250}.

Subcellular Localization

Cell projection, cilium {ECO:0000269PubMed:19253336}.

Disease Associations

Tissue Specificity

Co-localizes with RABL2/RABL2A in the midpiece of elongated spermatids within the testis (at protein level). {ECO:0000269PubMed:23055941}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0042073	intraciliary transport

Cellular Component

GO:0005622	intracellular
GO:0005813	centrosome
GO:0005929	cilium
GO:0016020	membrane
GO:0030992	intraciliary transport particle B
GO:0097225	sperm midpiece
GO:0097228	sperm principal piece

Protein Structure and Domains

PDB ID

MGI:1914292

InterPro

IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF08477

PRINTS

PR00449

PIRSF

SMART

SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt