Version 5.4
Mus musculus Protein: Clps
Summary
InnateDB Protein IDBP-158669.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clps
Protein Name colipase, pancreatic
Synonyms 2200003J09Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000025062
InnateDB Gene IDBG-158667 (Clps)
Protein Structure
UniProt Annotation
Function Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.Enterostatin has a biological activity as a satiety signal. {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed by the pancreas.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008047 enzyme activator activity
Biological Process
GO:0007586 digestion
GO:0016042 lipid catabolic process
GO:0043085 positive regulation of catalytic activity
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:88421
InterPro IPR001981 Colipase
IPR017913 Colipase, N-terminal
IPR017914 Colipase, C-terminal
PFAM PF01114
PF02740
PRINTS PR00128
PIRSF
SMART SM00023
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CQC2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 109791
UniGene Mm.467403
RefSeq NP_079745
MGI ID
MGI Symbol Clps
OMIM
CCDS CCDS28581
HPRD
IMGT
EMBL AF414676 AF414677 AF414678 AF414679 AK008635 AK008815 AK008834 AK008839 AK008874 AK008879 AK019047 AK028141 BC042935
GenPept AAH42935 AAL40730 AAL40731 AAL40732 AAL40733 BAB25796 BAB25909 BAB25918 BAB25921 BAB25944 BAB25947 BAB31524 BAC25769

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca