InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atad1

Summary

InnateDB Protein

IDBP-158795.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atad1

Protein Name

ATPase family, AAA domain containing 1

Synonyms

4921525H23Rik; AW107648; Thorase;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069962

InnateDB Gene

IDBG-158793 (Atad1)

Protein Structure

UniProt Annotation

Function

ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA- stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent. {ECO:0000269PubMed:21496646}.

Subcellular Localization

Peroxisome. Cell junction, synapse, postsynaptic cell membrane.

Disease Associations

Tissue Specificity

Widely expressed with the highest expression in the brain and testis. In the brain, relatively high expression in hippocampal CA1 pyramidal cells (at protein level). {ECO:0000269PubMed:21496646}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0009378	four-way junction helicase activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0002092	positive regulation of receptor internalization
GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0007612	learning
GO:0007613	memory
GO:0051967	negative regulation of synaptic transmission, glutamatergic

Cellular Component

GO:0005739	mitochondrion
GO:0005778	peroxisomal membrane
GO:0016020	membrane
GO:0030054	cell junction
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:1915229

InterPro

IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR008824 DNA helicase, Holliday junction RuvB type, N-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00004
PF07724
PF13304
PF05496

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D5T0