InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nat1

Summary

InnateDB Protein

IDBP-158883.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nat1

Protein Name

N-acetyl transferase 1

Synonyms

Nat-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026677

InnateDB Gene

IDBG-158881 (Nat1)

Protein Structure

UniProt Annotation

Function

Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Isoniazid, 2-aminofluorene and anisidine are preferred substrates for NAT-1. No activity with p- aminobenzoic acid (PABA) nor SMZ.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004060	arylamine N-acetyltransferase activity
GO:0016407	acetyltransferase activity

Biological Process

GO:0001889	liver development
GO:0007507	heart development
GO:0007568	aging
GO:0008152	metabolic process
GO:0097068	response to thyroxine

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

MGI:97279

InterPro

IPR001447 Arylamine N-acetyltransferase

PFAM

PF00797

PRINTS

PR01543

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P50294

PhosphoSite

PhosphoSite-P50294

TrEMBL

Q9ER94

UniProt Splice Variant

Entrez Gene

17960

UniGene

Mm.14125

RefSeq

NP_032699

MGI ID

MGI Symbol

Nat1

OMIM

CCDS

CCDS22337

HPRD

IMGT

EMBL

AJ250123 AJ314650 AJ314651 AJ314652 AJ314653 BC119181 BC137747 CH466569 U35885 U37119

GenPept

AAA78942 AAA80667 AAI19182 AAI37748 CAC12844 CAC85410 CAC85411 CAC85412 CAC85426 EDL28704